Research on satisfaction of patients and medical personnel based on the new healthcare re-form:A case study in Shanghai / 中国卫生政策研究

Objective:To study the satisfaction of patients and medical personnel after the new health care re-form.Methods:Using questionnaire survey method, we interviewed patients and medical personnel in 4 comprehen-sive hospitals and 8 community hospitals.The number of questionnaire is 1001,the number of patient questionnaire is 499,the number of medical personnel questionnaire is 502.Results:The overall satisfaction of patients and medical personnel are good.The patient's overall satisfaction score was 3.95, the average satisfaction score of administrative supervision,hospital environment,service attitude and service ability is more than 4 points,the average satisfaction score of the knowledge publicity,drug supply,medical expenses,medical care system and medical processes is less than 4 points.The satisfaction degree of return of work of medical personnel is lowest,The satisfaction degree of work-ing environment is highest.Community hospital medical staff and patient satisfaction is generally better than general hospital.Conclusion:The overall satisfaction of medical personnel and patients is good in the Shanghai area.In the fu-ture,more should be done on knowledge publicity,strengthening diagnosis and treatment process optimizing,medical expense controlling,and the improvement of the social practice environment and working conditions.

Ryanodine receptor 1 and its potential gating mechanism: Recent progress / 第二军医大学学报

The ryanodine receptors (RyRs) are intracellular Ca2+ releasing channels on the sarcoplasmic reticulum membrane and play a pivotal role in theexcitation-contraction coupling of skeletal and cardiac muscles as well as other physiological processes. With the recent development of CryoEM and the improvement of data analysis technique, scientists from China, the United States and Germany have acquired high-quality RyR1 images at the total resolutions of 3. 8 Å (1 Å = 10-10 m), 4. 8 Å and 6. 1 Å, respectively, which have been published in the same issue of Nature in 2015. RyRls are homotetrameric complexes with a molecular mass of more than 2 200 000, mainly containing a cytoplasmic region composed of NTD, SPRY, P1, P2, B-sol and C-sol domains and a channel region composed of S1-S6, VSL and CTD domains. As the most common factor affecting the condition of RyRl, Ca2+ is able to bind the EF-hand subdomain in the cytoplasmic region, which further causes the conformational change and finally leads to the channel opening.